In contrast, the C 70–(EDA) 8 is nontoxic for mammalian cells due to different distributions of the negative charges in the cell membrane. Finally, C 70–(EDA) 8 leads to the cytoplast leakage of superbacteria. On the other hand, the hydrophobic surface on the C 70 part makes it easy to form a strong hydrophobic interaction with the inner membrane of bacteria. On one hand, amino groups on the EDA part make it easy to affix onto the outer membrane of multidrug resistance Escherichia coli by electrostatic interactions. The strong antibacterial ability of this material was attributed to its unique molecular structure. C 70–(EDA) 8), which reveals a high performance in killing superbacteria, and most importantly, it shows negligible toxicity to the mammalian cells. Herein, we report a novel amine group-modified fullerene derivative (C 70–(ethylenediamine) 8 abrr. Along with the rapid appearance of superbacteria with multidrug resistance, it is a challenge to develop new antibacterial materials to address this big issue.
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